Many gastric motility disorders, including gastroparesis, are caused by dysrhythmias occurring in the stomach musculature. Microwave ablation (MWA) offers potential as a minimally invasive endoscopic approach for targeted thermal destruction of the gastric musculature to disrupt irregular electrical rhythm within the stomach wall. An experimental study was conducted in a gel phantom to analyze the transient heating profile of a water-cooled 2.45 GHz MWA antenna enclosed within a PET balloon. Fiber-optic temperature sensors were used to collect temperature data at distances 1.5–7.5 mm from the balloon surface. Ablation profiles were also characterized in ex vivo porcine skeletal muscle. With 20 W applied power and cooling water temperature of 5 °C, temperature measured at 3.5 mm from the balloon surface exceeded the temperature at 1.5 mm from the balloon surface by 3 °C. In ex vivo tissue, for 40 W applied power, tissue within 2 mm of the balloon surface remained unablated. With adequate cooling and power, it may be feasible to thermally spare tissue within 2 mm of the MWA balloon applicator.
Microwave Ablation: A Potential Minimally Invasive Solution for Gastric Motility Disorders
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Hardenburger, J, Prakash, P, Angeli, TR, & Cheng, LK. "Microwave Ablation: A Potential Minimally Invasive Solution for Gastric Motility Disorders." Proceedings of the 2019 Design of Medical Devices Conference. 2019 Design of Medical Devices Conference. Minneapolis, Minnesota, USA. April 15–18, 2019. V001T06A010. ASME. https://doi.org/10.1115/DMD2019-3293
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